| 產(chǎn)品名稱： |
辛伐他汀雜質(zhì)H |
| 中文別名： |
6(R)-[2-(8(S)-羥基]-2(S),6(R)-二甲基-1,2,6,7,8,8a(R)-六氫-1（S）-萘基]乙基-4（R）-羥基-3,4,5,6-四氫-2H-吡喃-2-酮;6(R)-[2-(8(s)-羥基]-2(s),6(r)-二甲基-1,2,6,7,8,8a(r)-六氫-1(s)-萘]乙基-4(r)-羥基-3,4,5,6-四氫-2H-吡喃-2-酮;辛伐他汀內(nèi)酯二醇;辛伐他汀雜質(zhì)H;洛伐他汀二醇內(nèi)酯 |
| 英文名稱： |
(4R,6R)-4-Hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one |
| 英文別名： |
(4R,6R)-4-Hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy;(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-h...;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro...;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-py;6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-diMethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one;Antibiotic MB 530A;Monacolin J;(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one |
| 品牌： |
PERFEMIKER |
| CAS號： |
79952-42-4 |
| 分子式： |
C19H28O4 |
| 分子量： |
320.42 |
| 純度： |
≥99.0% |
| 詳細描述： |
辛伐他汀內(nèi)酯二醇用途 Monacolin J 是膽固醇合成抑制劑，能夠抑制 HMG-CoA reductase 的活性。辛伐他汀系列雜質(zhì)，用于辛伐他汀藥物研發(fā)中的有關(guān)物質(zhì)研究和檢查。提供質(zhì)量證書COA（含工藝路線、詳細結(jié)構(gòu)確證圖譜解析、含量標定等）。 辛伐他汀內(nèi)酯二醇生物活性 描述Monacolin J 是膽固醇合成抑制劑，能夠抑制 HMG-CoA reductase 的活性。 相關(guān)類別 信號通路 >> 代謝酶/蛋白酶 >> HMG-CoA還原酶(HMGCR) 研究領(lǐng)域 >> 代謝疾病 靶點 HMG-CoA reductase[1] 體外研究Monacolin J是膽固醇生物合成的抑制劑，并抑制HMG-CoA還原酶的活性。 Monacolin J的Na鹽在1.2μg/ mL時對還原酶產(chǎn)生50％的抑制[1]。 溶解度 體外： 在DMSO中10mM 儲備液 1 mM3.1209 mL15.6045 mL31.2090 mL 5 mM0.6242 mL3.1209 mL6.2418 mL 10 mM0.3121 mL1.5605 mL3.1209 mL 存儲 請將產(chǎn)品存放在分析證書中的建議條件下。 運輸室溫;可能會有所不同 SMILESO=C1C[C@H](O)C[C@@H](CC[C@H]2[C@@H](C)C=CC3=C[C@H](C)C[C@H](O)[C@]23[H])O1 參考文獻 [1]. Endo A, et al. Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J Antibiot (Tokyo). 1985 Mar;38(3):420-2. 相關(guān)活性 小分子瑞舒伐他汀鈣 | 氟伐他汀鈉 水合物 | 普伐他汀鈉 | 美伐他汀 | 尼可沙噴 | 克利貝特 | SR12813 | 3-羥基-3-甲基戊二酸 辛伐他汀內(nèi)酯二醇物理化學性質(zhì) 密度1.2±0.1 g/cm3 沸點535.7±50.0 °C at 760 mmHg 分子式C19H28O4 分子量320.423 閃點191.2±23.6 °C 精確質(zhì)量320.198761 PSA66.76000 LogP1.81 蒸汽壓0.0±3.2 mmHg at 25°C 折射率1.558 辛伐他汀內(nèi)酯二醇英文別名 Antibiotic MB 530A (4R,6R)-4-Hydroxy-6-{2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]ethyl}tetrahydro-2H-pyran-2-one 2H-Pyran-2-one, 6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-, (4R,6R)- Monacolin J (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-4-hydroxyoxan-2-one Lovastatin diol lactone Simvastatin EP Impurity H |
滬公網(wǎng)安備31011402010658號 
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